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Companies and pharmacies were able to sell cheaper alternatives to weight loss drugs Wegovy and Ozempic because of a shortage of a protein called semaglutide, which helps regulate appetite

Some formulations include additional ingredients like methylcobalamin or B12 , which may influence the microbiome differently than semaglutide alone

Slowing down the emptying of the stomach can lead to problems like abdominal pain, nausea/vomiting and constipation

It does not dramatically change overall drug exposure or total weekly efficacy

Last reviewed: July 8, 2026 Last updated: July 8, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

During the 4 months of treatment, I have had zero negative side effects